Induction of c-fos gene expression by spinal cord transection in Sus scrofa
| Autor: | Isaac D Frasier, Anthony L. Sica, Norman Gootman, Muhammad Anwar, Phyllis M Gootman, David A. Ruggiero |
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| Rok vydání: | 1997 |
| Předmět: |
biology
Swine Somatic cell General Neuroscience Cell Gene Expression Sensory system Anatomy medicine.disease Spinal cord c-Fos Gene product Disease Models Animal medicine.anatomical_structure Gene expression biology.protein medicine Animals Neurology (clinical) Proto-Oncogene Proteins c-fos Molecular Biology Spinal cord injury Spinal Cord Injuries Developmental Biology |
| Zdroj: | Brain Research. 759:301-305 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/s0006-8993(97)00363-6 |
| Popis: | Functional responses of primary sensory afferents and spinal cord were monitored in swine subjected to a high cervical (C1) spinal transection. Two and a half hours after transection, dorsal root ganglia and cervical and thoracolumbar spinal segments were processed immunocytochemically for the c-fos gene product, Fos and related antigens. In spinal-transected animals, Fos-like immunoreactivity (FLI) was induced in spinal laminae I, V, VII and X and the intermediolateral cell column but not in sensory ganglia as compared to controls: spinal-intact age-matched littermates. Spinal laminae expressing FLI harbor sympathetic and somatic interneurons and may aid in maintaining sympathetic outflow. |
| Databáze: | OpenAIRE |
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