Effect of essential fatty acid deficiency on membrane fatty acid content and growth hormone stimulation of rat pituitaries during postnatal development
| Autor: | M.L. Alessio, M.C.F. Soares, M T Bluet-Pajot, C.L. Leger, C Kordon, Hubert Clauser, D.E. Wandscheer, A Enjalbert |
|---|---|
| Přispěvatelé: | Universidade Federal de Pernambuco, Partenaires INRAE, Elevage des ruminants en régions chaudes (UMR ERRC), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA), Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
phospholipide
medicine.medical_specialty Pituitary gland déficience Offspring [SDV]Life Sciences [q-bio] Stimulation QD415-436 Biology Biochemistry hormone de croissance 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Anterior pituitary Internal medicine medicine Weaning [INFO]Computer Science [cs] ComputingMilieux_MISCELLANEOUS 030304 developmental biology 2. Zero hunger chemistry.chemical_classification 0303 health sciences acide gras Fatty acid food and beverages Cell Biology Oleic acid medicine.anatomical_structure chemistry hypophyse Arachidonic acid acide arachidonique 030217 neurology & neurosurgery |
| Zdroj: | Journal of Lipid Research Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 1995, 36 (6), pp.1401-1406 Journal of Lipid Research 6 (36), 1401-1406. (1995) Journal of Lipid Research, Vol 36, Iss 6, Pp 1401-1406 (1995) |
| ISSN: | 0022-2275 |
| Popis: | Fatty acid composition of anterior pituitary cell membranes of rats deprived of essential fatty acids (EFA) and of rats receiving a standard diet was determined during postnatal development and in adults. Pregnant rats were fed an EFA-deficient diet and the offspring were fed the same diet after weaning. In parallel, effects of the diet on growth and on growth hormone (GH) responsiveness to GHRH stimulation were determined in control animals. Membrane content of arachidonic acid (20:4n-6) and of its elongation product adrenic acid (22:4n-6) increased regularly from day 2 to day 12 after birth. EFA-deficiency resulted on day 2 in increased oleic acid and in substitution of arachidonic and adrenic acids by corresponding elongation-desaturation products of oleic acid: eicosatrienoic (20:3n-9) and docosatrienoic (22:3n-9) acids. At the age of 24 days, n-9 series fatty acid reached the same level as in adult animals. Two-day-old EFA-deficient rats paradoxically exhibited a higher level of 20:4n-6 as compared to control rats. EFA-deficiency also decreased growth rate and GH pituitary responses to GHRH during the prepubertal period. These results suggest that changes in the lipid structure and in pituitary secretion properties elicited by EFA-deficiency depend upon the stage of development. |
| Databáze: | OpenAIRE |
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