Effects of gold nanoparticles on erythrocyte hemolysis

Autor:	O. I. Skotnikova, V. I. Sergienko, O. A. Azizova, E. M. Beckman, O. N. Shcheglovitova, L. B. Dudnik, A. V. Aseichev
Rok vydání:	2012
Předmět:	Chromatography Erythrocytes Chemistry Nanoparticle Metal Nanoparticles General Medicine medicine.disease Hemolysis General Biochemistry Genetics and Molecular Biology In vitro Colloidal gold Osmotic Pressure medicine Tonicity Osmotic pressure Humans Gold Particle Size Ex vivo Whole blood
Zdroj:	Bulletin of experimental biology and medicine. 156(4)
ISSN:	1573-8221
Popis:	We studied hemolytic activity of gold nanoparticles added to the whole blood (ex vivo) and of nanoparticles coated and not coated with plasma components on erythrocytes in hypotonic medium (osmotic hemolysis) in vitro. Gold nanoparticles did not stimulate erythrocyte hemolysis after 4-h incubation with the whole blood ex vivo. Hemolysis tended to increase in the presence of small gold nanoparticles (5, 10, 20 nm) at the maximum concentration of 20 μM (by gold content) used in our study in comparison with the control. This tendency was detected during the 1st hour of the nanoparticles incubation with blood. Gold nanoparticles in the used concentrations (up to 20 μM of gold) coated with plasma components after preincubation with autologous plasma and nanoparticles without coating caused no osmotic hemolysis of erythrocytes in vitro.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d007dfae7947557f326935ca8be4bfcd https://pubmed.ncbi.nlm.nih.gov/24771436 Zobrazit plný text záznamu Full text from SpringerLink