Geographic clonal tracking in macaques provides insights into HSPC migration and differentiation
| Autor: | Rong Lu, Samson J. Koelle, Mario Roederer, E. Lake Potter, Xing Fan, Di Yang, Diego A. Espinoza, Chuanfeng Wu, Brian Li, Cynthia E. Dunbar, Robert E. Donahue |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Time Factors Cellular differentiation T cell Immunology CD34 Bone Marrow Cells News Biology Insights Immunophenotyping Clonal Evolution 03 medical and health sciences Bone Marrow Cell Movement medicine Animals Immunology and Allergy Cell Lineage Progenitor cell Hematopoietic Stem Cell Transplantation Cell Differentiation Hematopoietic Stem Cells Macaca mulatta Hematopoiesis Cell biology Transplantation Haematopoiesis 030104 developmental biology medicine.anatomical_structure Cellular Microenvironment Cell Tracking Lymph Nodes Bone marrow Biomarkers |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.20171341 |
| Popis: | In this issue of JEM, Wu et al. use genetic barcoding of macaque hematopoietic stem cells to demonstrate that, after transplantation, HSCs are very asymmetrically distributed and uncover a thymus-independent pathway for mature T cell production in the bone marrow In this issue of JEM, Wu et al. (https://doi.org/10.1084/jem.20171341) use genetic barcoding of macaque hematopoietic stem cells to demonstrate that, after transplantation, HSCs are very asymmetrically distributed and uncover a thymus-independent pathway for mature T cell production in the bone marrow. |
| Databáze: | OpenAIRE |
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