Biotransformations of the cardiovascular drugs mexrenone and canrenone
| Autor: | Graham Byng, Jodi A Laakso, Ursula M Mocek, Ping T. Wang, Carol L Preisig, Baez Julio A |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Magnetic Resonance Spectroscopy
Bioconversion Metabolite Pharmaceutical Science Spironolactone Analytical Chemistry Hydroxylation chemistry.chemical_compound Mortierella Biotransformation Canrenone Drug Discovery medicine Corynespora cassiicola Chromatography High Pressure Liquid Pharmacology chemistry.chemical_classification biology Molecular Structure Organic Chemistry Fungi Cardiovascular Agents Stereoisomerism biology.organism_classification Complementary and alternative medicine chemistry Biochemistry Fermentation Molecular Medicine Lactone medicine.drug |
| Zdroj: | Journal of natural products. 66(3) |
| ISSN: | 0163-3864 |
| Popis: | Microbial transformation studies of the cardiovascular drugs mexrenone (1) and canrenone (2) were conducted. Thirty-nine biotransformations of mexrenone and 84 biotransformations of canrenone were analyzed. Metabolism of the substrate was observed in the majority of these cases. Several monohydroxylated derivatives were detected by HPLC-MS-UV and subsequently identified. Two new mexrenone derivatives, 11alpha- (3) and 12beta-hydroxymexrenone (4), and the known metabolite 6beta-hydroxymexrenone (5) were isolated as major products produced by the Beauveria bassiana ATCC 13144 bioconversion (3) and the Mortierella isabellina bioconversion (4 and 5), respectively. Single-elimination products were also sought; however, only the production of the known metabolite Delta(1,2)-mexrenone (6) by several bacteria was confirmed. One new monohydroxylated derivative of canrenone, 9alpha-hydroxycanrenone (7), was isolated as a major product from the Corynespora cassiicola bioconversion. Structure elucidation of all metabolites was based on NMR and HRMS analyses. |
| Databáze: | OpenAIRE |
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