Mitochondrial energetic metabolism perturbations in skeletal muscles and brain of zebrafish (Danio rerio) exposed to low concentrations of waterborne uranium
| Autor: | Christelle Adam-Guillermin, Sandrine Frelon, Daniel Brèthes, Jean-Paul Bourdineaud, Adélaïde Lerebours, Magali Floriani, Virginie Camilleri, Jacqueline Garnier-Laplace |
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| Přispěvatelé: | Laboratoire de Radioécologie et d'Ecotoxicologie (DEI/SECRE/LRE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Institut de biochimie et génétique cellulaires (IBGC), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2010 |
| Předmět: |
Fish Proteins
Water Pollutants Radioactive medicine.medical_specialty Health Toxicology and Mutagenesis Cell Respiration Danio [SDV.BC]Life Sciences [q-bio]/Cellular Biology 010501 environmental sciences Aquatic Science Mitochondrion Biology 01 natural sciences 03 medical and health sciences Internal medicine Respiration medicine Animals Myocyte Muscle Skeletal Toxicity Tests Chronic Inner mitochondrial membrane Zebrafish ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0105 earth and related environmental sciences 0303 health sciences Brain Aquatic animal Anatomy biology.organism_classification Mitochondria Mitochondria Muscle Endocrinology Electron Transport Chain Complex Proteins 13. Climate action Toxicity Uranium Myofibril |
| Zdroj: | Aquatic Toxicology Aquatic Toxicology, Elsevier, 2010, 100 (1), pp.66-74. ⟨10.1016/j.aquatox.2010.07.007⟩ |
| ISSN: | 0166-445X |
| Popis: | Anthropogenic release of uranium (U), originating from the nuclear fuel cycle or military activities, may considerably increase U concentrations in terrestrial and aquatic ecosystems above the naturally occurring background levels found throughout the environment. With a projected increase in the world-wide use of nuclear power, it is important to improve our understanding of the possible effects of this metal on the aquatic fauna at concentrations commensurate with the provisional drinking water guideline value of the World Health Organization (15 μg U/L). The present study has examined the mitochondrial function in brain and skeletal muscles of the zebrafish, Danio rerio, exposed to 30 and 100 μg/L of waterborne U for 10 and 28 days. At the lower concentration, the basal mitochondrial respiration rate was increased in brain at day 10 and in muscles at day 28. This is due to an increase of the inner mitochondrial membrane permeability, resulting in a decrease of the respiratory control ratio. In addition, levels of cytochrome c oxidase subunit IV (COX-IV) increased in brain at day 10, and those of COX-I increased in muscles at day 28. Histological analyses performed by transmission electron microscopy revealed an alteration of myofibrils and a dilatation of endomysium in muscle cells. These effects were largest at the lowest concentration, following 28 days of exposure. |
| Databáze: | OpenAIRE |
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