Skeletal muscle expression of class II histocompatibility antigens (HLA-DR) in polymyositis and other muscle disorders with an inflammatory infiltrate
| Autor: | J A Zuk, A Fletcher |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Pathology
medicine.medical_specialty Muscle disorder Biology Polymyositis Muscular Dystrophies Pathology and Forensic Medicine Biopsy medicine HLA-DR Humans Muscular dystrophy Motor Neurons HLA-D Antigens Muscle biopsy Myositis medicine.diagnostic_test Muscles Skeletal muscle HLA-DR Antigens Neuromuscular Diseases General Medicine medicine.disease medicine.anatomical_structure Immunology ITGA7 Research Article |
| Zdroj: | Journal of Clinical Pathology. 41:410-414 |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.41.4.410 |
| Popis: | Muscle biopsy specimens with a pronounced inflammatory component were evaluated for myocyte expression of class II histocompatibility antigens (HLA-DR) by immunohistochemical techniques. All 15 cases of polymyositis were positive; six cases of muscular dystrophy (two Duchenne, four facio-scapulo-humeral), and one case of acute denervation (motor neurone disease) were negative, despite having a comparably intense mononuclear infiltrate. Twelve entirely normal biopsy specimens were also negative for HLA-DR expression. Expression of this membrane glycoprotein may have a clinically important aetiological role in polymyositis, and demonstration of its presence may prove useful as a marker for this disorder in selected problematic biopsy specimens. |
| Databáze: | OpenAIRE |
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