Orointestinal yeast colonization of paediatric bone marrow transplant recipients: surveillance by quantitative culture and serology
| Autor: | J E Hoppe, T. Klingebiel, Dietrich Niethammer |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Opportunistic infection Premedication medicine.medical_treatment Dermatology Biology Gastroenterology Serology Feces Internal medicine Amphotericin B medicine Humans Longitudinal Studies Prospective Studies Child Fluconazole Antibodies Fungal Mycosis Bone Marrow Transplantation Candida Mouth Infant Immunosuppression General Medicine medicine.disease Infectious Diseases medicine.anatomical_structure Child Preschool Concomitant Immunology Female Bone marrow medicine.drug |
| Zdroj: | Mycoses. 38:51-57 |
| ISSN: | 1439-0507 0933-7407 |
| DOI: | 10.1111/j.1439-0507.1995.tb00008.x |
| Popis: | We quantitatively studied the orointestinal yeast colonization of 15 consecutive paediatric patients who underwent 16 bone marrow transplantations (BMT). Cultures were performed initially, longitudinally weekly during the period of aplasia (in-patient treatment) and, if possible, also during out-patient follow-up. With one exception, all patients received fluconazole as antifungal prophylaxis. Patients remained free of yeasts during the complete observation period only in six out of 16 cases (38%). Non-albicans species of Candida were isolated in six out of 16 cases (38%), mainly C. glabrata (five out of 16; 31%). All of these patients had undergone allogeneic BMT. In one case, there was indirect evidence of systemic invasion by C. glabrata. Even combined prophylaxis with fluconazole and and amphotericin B suspension could not reliably prevent yeast colonization but this combination at present appears to be the optimal regime. Regular concomitant Candida serology (determination of specific antibodies by three methods) proved to be a valuable additional surveillance method. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text