Methyldopa Versus Nifedipine or No Medication for Treatment of Chronic Hypertension During Pregnancy: A Multicenter Randomized Clinical Trial
| Autor: | Wael Gaber, Sameh Abdallah, Hala Marawan, Mohamed Rezk, Mohamed Salama, Awni Gamal, Haitham A Hamza |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Nifedipine medicine.drug_class Pregnancy Complications Cardiovascular Administration Oral 030204 cardiovascular system & hematology law.invention Preeclampsia 03 medical and health sciences Young Adult 0302 clinical medicine Randomized controlled trial Pregnancy law Prenatal Diagnosis Internal medicine Internal Medicine medicine Humans Methyldopa Antihypertensive drug Antihypertensive Agents Fetus 030219 obstetrics & reproductive medicine Placental abruption business.industry Infant Newborn Obstetrics and Gynecology Hypertension Pregnancy-Induced General Medicine medicine.disease Treatment Outcome Hypertension Egypt Female business medicine.drug |
| Zdroj: | Obstetrical & Gynecological Survey. 75:719-720 |
| ISSN: | 1533-9866 0029-7828 |
| DOI: | 10.1097/01.ogx.0000723724.26802.a1 |
| Popis: | To assess the maternal and fetal outcome in women with mild to moderate chronic hypertension on antihypertensive drug (methyldopa or nifedipine) therapy compared to no medication.This multicenter randomized clinical trial was conducted at Menoufia University hospital, Shibin El-kom Teaching hospital and 11 Central hospitals at Menoufia governorate, Egypt.490 pregnant women with mild to moderate chronic hypertension were randomized into three groups; methyldopa group (n = 166), nifedipine group (n = 160) and control or no medication group (n = 164) who were followed from the beginning of pregnancy till the end of puerperium to record maternal and fetal outcome.Mothers in the control (no medication) group were more prone for the development of severe hypertension, preeclampsia, renal impairment, ECG changes, placental abruption and repeated hospital admissions (p 0.001) when compared to mothers in both treatment groups (methyldopa and nifedipine). Neonates in the control (no medication) group were more prone for prematurity and admission to neonatal ICU (p 0.001).Antihypertensive drug therapy is advisable in mild to moderate chronic hypertension during pregnancy to decrease maternal and fetal morbidity. When considering which agents to use for treatment, oral methyldopa and nifedipine are valid options. |
| Databáze: | OpenAIRE |
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