Aptamer-Gold Nanocage Composite for Photoactivated Immunotherapy

Autor:	Wen Song, Jing-Jing Hu, Shu-Jun Song, Yi Xu, Hang Yang, Fan Yang, Ying Zhou, Tao Yu, Wen-Xiu Qiu
Rok vydání:	2022
Předmět:	Dimaprit Cell Line Tumor Neoplasms Programmed Cell Death 1 Receptor Humans General Materials Science Gold Immunotherapy Aptamers Nucleotide Immune Checkpoint Inhibitors Nanostructures
Zdroj:	ACS Applied Materials & Interfaces. 14:42931-42939
ISSN:	1944-8252 1944-8244
DOI:	10.1021/acsami.2c11089
Popis:	Immune checkpoint blockade (ICB) has been hailed as the hope for conquering cancer as ICB could produce a significant and durable response to tumor cells. However, the high cost and severe side effects of ICB drugs limited their application for further anticancer therapy. Here, we developed a photoactivated immunotherapy nanoplatform (Apt@AuNC). This nanoplatform could target tumor tissues via enhanced penetration retention (EPR) effect and the aptamer (Apt) could be released from Apt@AuNC in tumor sites via illumination. The immune system in the tumor area was then activated after the combination of Apt and PD-1 protein. The heat generated from AuNC was able to continue killing tumor cells. This nanoplatform could not only achieve the precise immunotherapy but also significantly facilitate the anticancer efficacy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8cd1a6e5d2ab9bb13894b6066fbfe4 https://doi.org/10.1021/acsami.2c11089 Zobrazit plný text záznamu