Loss of D2 receptor binding with age in rhesus monkeys: importance of correction for differences in striatal size
| Autor: | Ali A. Bonab, Donald K. Ingram, Steven J. Grant, Mark A. Lane, Victor L. Villemagne, Edythe D. London, Robert F. Dannals, Dean F. Wong, John A. Matochik, George S. Roth, Evan D. Morris, Svetlana I. Chefer, Raymond F. Muzic |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Aging Partial volume Striatum Biology 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine In vivo Dopamine Internal medicine Dopamine receptor D2 medicine Animals Raclopride Receptors Dopamine D2 Putamen Binding potential Dopamine receptor binding Macaca mulatta Magnetic Resonance Imaging Corpus Striatum Endocrinology Neurology Neurology (clinical) Cardiology and Cardiovascular Medicine Neuroscience 030217 neurology & neurosurgery medicine.drug Tomography Emission-Computed |
| Zdroj: | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 19(2) |
| ISSN: | 0271-678X |
| Popis: | The relation between striatal dopamine D2 receptor binding and aging was investigated in rhesus monkeys with PET. Monkeys (n = 18, 39 to 360 months of age) were scanned with 11C-raclopride; binding potential in the striatum was estimated graphically. Because our magnetic resonance imaging analysis revealed a concomitant relation between size of striatum and age, the dynamic positron emission tomography (PET) data were corrected for possible partial volume (PV) artifacts before parameter estimation. The age-related decline in binding potential was 1% per year and was smaller than the apparent effect if the age-related change in size was ignored. This is the first in vivo demonstration of a decline in dopamine receptor binding in nonhuman primates. The rate of decline in binding potential is consistent with in vitro findings in monkeys but smaller than what has been measured previously in humans using PET. Previous PET studies in humans, however, have not corrected for PV error, although a decline in striatal size with age has been demonstrated. The results of this study suggest that PV correction must be applied to PET data to accurately detect small changes in receptor binding that may occur in parallel with structural changes in the brain. |
| Databáze: | OpenAIRE |
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