Plasma concentrations of carminomycin and carminomycinol in man, measured by high pressure liquid chromatography
| Autor: | Jan Lankelma, Herbert M. Pinedo, A. Leyva, M.M. De Planque, Paul G.M. Penders, J.G. McVie, W. W. ten Bokkel-Huinink |
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| Přispěvatelé: | VU University medical center |
| Jazyk: | angličtina |
| Rok vydání: | 1982 |
| Předmět: |
Time Factors
Chromatography Carminomycinol Chemistry Carubicin Metabolite Daunorubicin Breast Neoplasms Sarcoma Soft Tissue Neoplasms High-performance liquid chromatography Malignant disease chemistry.chemical_compound Oncology Plasma concentration Toxicity Humans In patient Chromatography High Pressure Liquid Bolus injection |
| Zdroj: | European Journal of Cancer and Clinical Oncology, 18. Pergamon Press Lankelma, J, Penders, P G M, McVie, J G, Leyva, A, ten Bokkel Huinink, W W, de Planque, M M & Pinedo, H M 1982, ' Plasma concentrations of carminomycin and carminomycinol in man, measured by high pressure liquid chromatography ', European Journal of Cancer and Clinical Oncology, vol. 18, pp. 363 . |
| ISSN: | 0277-5379 |
| Popis: | In 9 patients with advanced malignant disease who received carminomycin (CMM) in an i.v. bolus injection (dose 18 mg / m 2 ), curves of plasma concentrations of CMM and carminomycinol (CMMOH), a metabolite, versus time were constructed. For determination of plasma concentrations, high pressure liquid chromatography was used. For CMM and CMMOH the median areas under the curves (AUC's) were 31 (range 4–57) × 10 −8 mol/l/hr (measured over 24 hr ) and 100 (range 30–158) × 10 −8 mol/l/hr (measured over 48 hr ) respectively. From the data an accumulation of CMMOH in patients receiving treatments separated by brief intervals can be predicted (half-life time of plasma disappearance for CMMOH was 2 days ). Clinical toxicity was lowest in those 3 patients showing the lowest AUC for both CMM and CMMOH. |
| Databáze: | OpenAIRE |
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