Natural killer cell-target cell interactions
| Autor: | Tuomo Timonen, Tuula Helander |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Cytotoxicity
Immunologic 0303 health sciences Lymphokine-activated killer cell Receptors Cell Surface Cell Biology Immune receptor Biology Cell biology Natural killer cell Killer Cells Natural 03 medical and health sciences Interleukin 21 0302 clinical medicine Cell killing medicine.anatomical_structure MHC class I Interleukin 12 medicine biology.protein Animals Humans Receptor 030304 developmental biology 030215 immunology |
| Zdroj: | Current opinion in cell biology. 9(5) |
| ISSN: | 0955-0674 |
| Popis: | Research into the molecular mechanisms of target cell recognition by natural killer (NK) cells has recently progressed rapidly. NK cells express several MHC I recognizing receptors that inactivate the NK cells' functions. In pathological alterations of MHC I expression, the NK cell inhibitory receptors do not engage and thus permit the lysis of the target cell. The receptors that trigger the cytolytic machinery of NK cells, after the permission of lysis from the inhibitory receptors, are poorly characterized. Some candidate triggering receptors have been identified and it seems that triggering of NK cell killing is mediated by multiple receptors, as is the inhibition of cytotoxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect