Pheophorbide a-methyl ester, acyl-coa: cholesterol acyltransferase inhibitor fromDiospyros kaki
| Autor: | Oh Eok Kwon, Koanhoi Kim, Mun-Chual Rho, Seung Woong Lee, Hyun Sun Lee, Young-Kook Kim, Hye Young Song, Jin Ah Baek, Kyung Hee Jeune, Mi Yeon Chung |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Chlorophyll
Methyl Ethers Sterol O-acyltransferase Gas Chromatography-Mass Spectrometry chemistry.chemical_compound Acyl-CoA Drug Discovery Animals IC50 Chromatography High Pressure Liquid Korea Dose-Response Relationship Drug Molecular Structure biology Plant Extracts Methanol Organic Chemistry Diospyros kaki Diospyros biology.organism_classification Rats Plant Leaves chemistry Biochemistry Pheophorbide A Microsomes Liver Molecular Medicine ACAT activity Acyl Coenzyme A Drugs Chinese Herbal Sterol O-Acyltransferase |
| Zdroj: | Archives of Pharmacal Research. 26:716-718 |
| ISSN: | 1976-3786 0253-6269 |
| DOI: | 10.1007/bf02976679 |
| Popis: | In the course of our search for Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from a methanol extract of Diospyros kaki. On the basis of spectral and structural evidence, the compound was identified as pheophorbide A-methyl ester. Pheophorbide A-methyl ester inhibited ACAT activity in a dose dependent manner with an IC50 value of 1.85 microg/mL. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink