The cytokine macrophage migration inhibitory factor (MIF) acts as a neurotrophin in the developing inner ear of the zebrafish, Danio rerio

Autor: Alexander Chong Shu-Chien, Karen L. Wu, Meng-Kiat Kuah, Kah Loon Wong, Ethan M. Jewett, Kate F. Barald, Yu Chi Shen, Deborah L. Thompson, Stephanie A. Linn
Rok vydání: 2012
Předmět:
Nervous system
Embryo
Nonmammalian
Time Factors
Cellular differentiation
Sensory HC
animal diseases
Statoacoustic ganglion
Hydroxamic Acids
0302 clinical medicine
Ganglia
Sensory
Inner ear
Receptors
Immunologic
Zebrafish
Macrophage migration inhibitory factor
0303 health sciences
biology
Reverse Transcriptase Polymerase Chain Reaction
Gene Expression Regulation
Developmental
Cell Differentiation
Cell biology
medicine.anatomical_structure
Gene Knockdown Techniques
Neurotrophin
Neural development
Neurite
Sensory Receptor Cells
chemical and pharmacologic phenomena
Article
03 medical and health sciences
Hair Cells
Auditory
medicine
otorhinolaryngologic diseases
Animals
Immune cytokines
Nerve Growth Factors
Macrophage Migration-Inhibitory Factors
Molecular Biology
030304 developmental biology
Gene Expression Profiling
Semicircular canal formation
Cell Biology
Zebrafish Proteins
biology.organism_classification
Molecular biology
Semicircular Canals
Histone Deacetylase Inhibitors
Pyrimidines
Ear
Inner
biology.protein
sense organs
030217 neurology & neurosurgery
Developmental Biology
Zdroj: Developmental Biology. 363(1):84-94
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2011.12.023
Popis: Macrophage migration inhibitory factor (MIF) plays versatile roles in the immune system. MIF is also widely expressed during embryonic development, particularly in the nervous system, although its roles in neural development are only beginning to be understood. Evidence from frogs, mice and zebrafish suggests that MIF has a major role as a neurotrophin in the early development of sensory systems, including the auditory system. Here we show that the zebrafish mif pathway is required for both sensory hair cell (HC) and sensory neuronal cell survival in the ear, for HC differentiation, semicircular canal formation, statoacoustic ganglion (SAG) development, and lateral line HC differentiation. This is consistent with our findings that MIF is expressed in the developing mammalian and avian auditory systems and promotes mouse and chick SAG neurite outgrowth and neuronal survival, demonstrating key instructional roles for MIF in vertebrate otic development.
Databáze: OpenAIRE
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