Gomesin acts in the immune system and promotes myeloid differentiation and monocyte/macrophage activation in mouse
| Autor: | Edgar J. Paredes-Gamero, Amanda Nogueira-Pedro, Christiano M.V. Barbosa, Marcus V. Buri, Carol C. Dias, Antonio Miranda, Antonio C. Ribeiro-Filho |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Physiology T-Lymphocytes CD3 Antimicrobial peptides Biology Biochemistry Monocytes Immunomodulation Mice 03 medical and health sciences Cellular and Molecular Neuroscience Endocrinology Immune system medicine Animals Macrophage Cytotoxic T cell Myeloid Cells Cytotoxicity Monocyte Cell Differentiation Macrophage Activation Molecular biology Haematopoiesis 030104 developmental biology medicine.anatomical_structure Immune System Immunology biology.protein Antimicrobial Cationic Peptides |
| Zdroj: | Peptides. 85:41-45 |
| ISSN: | 0196-9781 |
| Popis: | Due to the cytotoxic effect of antimicrobial peptides (AMP) against several microorganism and tumor cells has been proposed their association with the immune system. However, just a few reports have shown this relationship. In this study, mice were treated with gomesin, a β-hairpin AMP that exhibit high cytotoxicity against bacterial and tumor cells. Different effects in the immune system were observed, such as, decrease of CD3+ in T lymphocytes (Control: 17.7±1.4%; Gomesin: 7.67±1.2%) and in hematopoietic progenitors and increase of hematopoietic stem cell (Control: 0.046±0.004%; Gomesin: 0.067±0.003%), B220+ B lymphocytes (Control: 38.63±1.5%; Gomesin: 47.83±0.48%), and Mac-1+F4/80+ macrophages (Control: 11.76±3.4%; Gomesin: 27.13±4.0%). Additionally, macrophage increase was accompanied by an increase of macrophage phagocytosis (Control 20.85±1.53; Gomesin 31.32±1 Geometric mean), interleukin 6 (Control: 47.24±1.9ng/mL; Gomesin: 138.68±33.68ng/mL) and monocyte chemoattractant protein-1 (Control: 0.872±0.093ng/mL; Gomesin: 1.83±0.067ng/mL). Thus, this report showed immunomodulatory activity of gomesin in the immune system of mice. |
| Databáze: | OpenAIRE |
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