Reinnervation as measured by the motor unit size index is associated with preservation of muscle strength in amyotrophic lateral sclerosis, but not all muscles reinnervate
| Autor: | Christopher J McDermott, José Castro Tech, Thomas M Jenkins, Young Chan, Paul E. Barkhaus, Pamela J. Shaw, Sanjeev D. Nandedkar, Christoph Neuwirth, Mamede de Carvalho, Erik Stålberg, Markus Weber, James J.P. Alix |
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| Rok vydání: | 2021 |
| Předmět: |
Weakness
medicine.medical_specialty Physiology Biceps Cellular and Molecular Neuroscience Physical medicine and rehabilitation Physiology (medical) Abductor digiti minimi Medicine Humans Muscle Strength Amyotrophic lateral sclerosis Muscle Skeletal Motor Neurons business.industry Electromyography Amyotrophic Lateral Sclerosis medicine.disease Compound muscle action potential Motor unit medicine.anatomical_structure Muscle strength Neurology (clinical) medicine.symptom business Reinnervation |
| Zdroj: | MusclenerveREFERENCES. 65(2) |
| ISSN: | 1097-4598 |
| Popis: | INTRODUCTION: The motor unit size index (MUSIX) may provide insight into reinnervation patterns in diseases such as amyotrophic lateral sclerosis (ALS). However, it is not known if MUSIX detects clinically relevant changes in reinnervation, or if all muscles manifest changes in MUSIX in response reinnervation following motor unit loss. METHODS: 57 patients with ALS were assessed at 3-monthly intervals for 12 months in 4 centres. Muscles examined were abductor pollicis brevis, abductor digiti minimi, biceps brachii and tibialis anterior. Results were split into two groups: muscles with increases in MUSIX and those without. Longitudinal changes in MUSIX, motor unit number index (MUNIX), compound muscle action potential (CMAP) amplitude and medical research council (MRC) strength score were investigated. RESULTS: 133 muscles were examined. 59% of muscles exhibited an increase in MUSIX during the study. Muscles with MUSIX increases lost more motor units (MUNIX decline at 12 months -58%, p |
| Databáze: | OpenAIRE |
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