Overexpression of SOX11 and TFE3 in Solid-Pseudopapillary Neoplasms of the Pancreas
| Autor: | Shannon J. McCall, Cynthia D. Guy, Diana M. Cardona, Amanda Hemmerich, Xuefeng Zhang, Grant Harrison, Kathryn Perkinson, Debra Fleming |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty Adolescent TFE3 Neuroendocrine tumors Sensitivity and Specificity SOXC Transcription Factors Cohort Studies Pathogenesis Young Adult 03 medical and health sciences 0302 clinical medicine Biomarkers Tumor Acinar cell Humans Medicine Child Pancreas Aged Clinical pathology Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Carcinoma Acinar Cell business.industry Diagnostic marker General Medicine Middle Aged medicine.disease Immunohistochemistry Pancreatic Neoplasms Neuroendocrine Tumors 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Female business |
| Zdroj: | American Journal of Clinical Pathology. 149:67-75 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1093/ajcp/aqx142 |
| Popis: | Objectives To characterize the expression of SOX11 and TFE3 proteins in solid-pseudopapillary neoplasms (SPNs) and their histologic mimickers. Methods Immunohistochemistry for SOX11, TFE3, and β-catenin was performed on 31 cases of surgically resected SPNs. Neuroendocrine tumors, acinar cell carcinomas, and pancreatoblastomas served as controls. Results Nuclear immunoreactivity for SOX11 was detected in all SPNs and five of 31 control tumors. Nuclear immunoreactivity for TFE3 was detected in 30 SPNs and three control tumors. Nuclear immunoreactivity for β-catenin was detected in all SPNs and four control tumors. The combination of three markers as immunohistochemical panels resulted in optimal sensitivity and specificity. Conclusions Both SOX11 and TFE3 were overexpressed in SPNs and may be involved in the pathogenesis. Clinically, SOX11 and TFE3 can be potentially used as diagnostic markers in distinguishing indeterminate SPNs from their histologic mimickers. |
| Databáze: | OpenAIRE |
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