Influence of the postexercise acquisition delay on the detection of functional abnormalities in sestamibi-gated SPECT

Autor: Manjola Dona, Roberto Sciagrà, Barbara Sotgia, Alberto Pupi
Rok vydání: 2006
Předmět:
Adult
Male
Technetium Tc 99m Sestamibi
medicine.medical_specialty
Myocardial ischemia
Time Factors
Gated SPECT
Ischemia
Myocardial Ischemia
Coronary Artery Disease
Single-photon emission computed tomography
coronary artery disease exercise stress testing gated single photon emission computed tomography Left ventricular function
Sensitivity and Specificity
Coronary artery disease
Ventricular Dysfunction
Left
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
skin and connective tissue diseases
Aged
Aged
80 and over
Tomography
Emission-Computed
Single-Photon
medicine.diagnostic_test
business.industry
Reproducibility of Results
Gated Blood-Pool Imaging
Image enhancement
Middle Aged
medicine.disease
Image Enhancement
Cardiology
Exercise Test
Female
sense organs
Radiopharmaceuticals
Cardiology and Cardiovascular Medicine
business
Nuclear medicine
Zdroj: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 14(3)
ISSN: 1532-6551
Popis: Gated single photon emission computed tomography (SPECT) identifies functional changes produced by ischemia, but the influence of acquisition delay on their detection is not established.In 80 patients with known or suspected coronary artery disease, gated SPECT was acquired twice: first, less than 30 minutes after peak exercise (stress 1), and second, more than 45 minutes after peak exercise (stress 2). End-diastolic volume (EDV), end-systolic volume (ESV), and ejection fraction (EF) were compared with perfusion. The relationship between the DeltaEF (stress EF - resting EF) and the summed difference score (SDS) was -0.443 (P.0001) for stress 1 and -0.416 (P.0001) for stress 2. In stress 1, EF increased in patients without inducible ischemia (SDS = 0) (57% +/- 10% vs 54% +/- 9% at rest, P.02) and decreased in those with an SDS of 1 or greater (53% +/- 10.8% vs 55% +/- 9.6% at rest, P.05). In stress 2, EF was unchanged in patients without ischemia (55.8% +/- 9.7%, P = .06) and decreased in the other patients (52.8% +/- 10.2%, P.01). In patients without ischemia, both the EDV and ESV decreased significantly in stress 1 and were unchanged in stress 2. In patients with an SDS of 1 or greater, the EDV remained unchanged and the ESV minimally decreased in stress 1, whereas both volumes clearly and significantly increased in stress 2.The early acquisition of postexercise gated SPECT is slightly more effective in detecting ischemia-related functional changes; however, a delayed acquisition within 60 minutes still permits the detection of functional abnormalities in most patients.
Databáze: OpenAIRE
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