Effect of piroxicam administration in infertile women undergoing assisted reproductive technologies: A systematic review and meta-analysis
| Autor: | Ahmed Mohamed Abdelhakim, Amr Salah Mohamed Hegab, Rehab Abdelhamid Aboshama, Doaa M Saleh, Kareem Labib, Ahmed Osama Abdel Motaal, Bassem Aly Islam, Ahmed M. Abbas |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pregnancy Rate Reproductive Techniques Assisted Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Reproductive technology Piroxicam law.invention 03 medical and health sciences 0302 clinical medicine Endocrinology Randomized controlled trial Pregnancy law Internal medicine Humans Medicine Pregnancy outcomes 030219 obstetrics & reproductive medicine business.industry Anti-Inflammatory Agents Non-Steroidal Obstetrics and Gynecology medicine.disease Abortion Spontaneous Meta-analysis Female business Infertility Female medicine.drug |
| Zdroj: | Gynecological Endocrinology. 37:785-791 |
| ISSN: | 1473-0766 0951-3590 |
| Popis: | To evaluate piroxicam effect on different pregnancy outcomes among infertile women undergoing assisted reproductive technologies (ART).We searched for the available randomized clinical trials (RCTs) in four different databases during January 2021 that compared piroxicam (intervention group) to placebo/no treatment (control group) in infertile women performing ART. We extracted the available data from included studies and pooled them in a meta-analysis model using RevMan software. We pooled the dichotomous data as risk ratios (RR) with the corresponding 95% confidence intervals (CI) using RevMan software. Our outcomes were rates of clinical pregnancy, ongoing pregnancy, miscarriage, and any adverse events.Seven RCTs met our inclusion criteria with a total number of 1226 patients. Piroxicam was linked to a significant increase in clinical pregnancy rate compared to control group (RR = 1.30, 95% CI [1.09, 1.55],Piroxicam administration increases the clinical pregnancy rate among infertile women. However, piroxicam does not affect miscarriage and ongoing pregnancy rates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|