Monoterpenoids from the aerial parts of Aruncus dioicus var. kamtschaticus and their antioxidant and cytotoxic activities
| Autor: | Do Youn Jun, Su Yang Jeong, Young Ho Kim, Mi Hee Woo, Bo Kyung Min, Byung Sun Min |
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| Rok vydání: | 2011 |
| Předmět: |
Magnetic Resonance Spectroscopy
Antioxidant Stereochemistry medicine.medical_treatment Monoterpene Clinical Biochemistry Pharmaceutical Science Antineoplastic Agents Apoptosis Pharmacognosy Biochemistry Antioxidants Aruncus dioicus Inhibitory Concentration 50 Jurkat Cells chemistry.chemical_compound Drug Discovery medicine Humans Hydroxymethyl Rosaceae Molecular Biology Cell Proliferation chemistry.chemical_classification Molecular Structure biology Plant Extracts Organic Chemistry Glycoside Plant Components Aerial biology.organism_classification Terpenoid chemistry Monoterpenes Molecular Medicine Lactone |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 21:3252-3256 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2011.04.043 |
| Popis: | The aerial parts of Aruncus dioicus var. kamtschaticus afforded five new monoterpenoids (1-5): 4-(erythro-6,7-dihydroxy-9-methylpent-8-enyl)furan-2(5H)-one (1, aruncin A), 2-(8-ethoxy-8-methylpropylidene)-5-hydroxy-3,6-dihydro-2H-pyran-4-carboxylic acid (2, aruncin B), 4-(hydroxymethyl)-6-(8-methylprop-7-enyl)-5,6-dihydro-2H-pyran-2-one-11-O-β-D-glucopyranoside (3, aruncide A), (3S,4S,5R,10R)-3-(10-ethoxy-11-hydroxyethyl)-4-(5-hydroxy-7-methylbut-6-enyl)oxetan-2-one-11-O-β-D-glucopyranoside (4, aruncide B), and (3S,4S,5R,7R)-5-(9-methylprop-8-enyl)-1,6-dioxabicyclo[3,2,0]heptan-2-one-7-(hydroxymethyl)-12-O-β-D-glucopyranoside (5, aruncide C). Compound 2 showed potent cytotoxicity against Jurkat T cells with an IC(50) value of 17.15 μg/mL. In addition, compounds 7 and 10 exhibited moderate antioxidant activity with IC(50) values of 46.3 and 11.7 μM, respectively. |
| Databáze: | OpenAIRE |
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