Correlation between asparaginase enzyme activity levels and coagulation parameters during childhood acute lymphoblastic leukemia treatment

Autor: Sofie Gottschalk Højfeldt, Kathrine Grell, Lone Hvitfeldt, Peder Skov Wehner, Jesper Bjerre, Birgitte Klug Albertsen
Rok vydání: 2022
Předmět:
Zdroj: Højfeldt, S G, Grell, K, Hvitfeldt, L, Wehner, P S, Bjerre, J & Albertsen, B K 2023, ' Correlation between asparaginase enzyme activity levels and coagulation parameters during childhood acute lymphoblastic leukemia treatment ', Pediatric Blood & Cancer, vol. 70, no. 2, e30085 . https://doi.org/10.1002/pbc.30085
Højfeldt, S G, Grell, K, Hvitfeldt, L, Wehner, P S, Bjerre, J & Albertsen, B K 2022, ' Correlation between asparaginase enzyme activity levels and coagulation parameters during childhood acute lymphoblastic leukemia treatment ', Pediatric Blood and Cancer . https://doi.org/10.1002/pbc.30085
ISSN: 1545-5017
DOI: 10.1002/pbc.30085
Popis: Thromboembolism is a serious toxicity in the treatment of acute lymphoblastic leukemia (ALL), but little is known about the correlation between asparaginase enzyme activity (ASA) levels and coagulation parameters. We included 65 non-high risk ALL patients, aged 1–17 years. Coagulation parameters and corresponding ASA levels were measured during asparaginase treatment. We found ASA to be negatively correlated with antithrombin and fibrinogen up to ASA levels of 250 IU/L, after which these parameters reached a plateau and did not decrease further with further increase of ASA. Patients with silent inactivation of asparaginase had normal coagulation parameters.
Databáze: OpenAIRE
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