Early amniocentesis: alphafetoprotein levels in amniotic fluid, extraembryonic coelomic fluid and maternal serum between 8 and 13 weeks
| Autor: | M. J. Kitau, Tim Chard, D.James Campbell, N. C. Wathen, P. L. Cass |
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| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Amniotic fluid Radioimmunoassay Ultrasonography Prenatal Pregnancy Reference Values Medicine Humans Fetus medicine.diagnostic_test business.industry Obstetrics Obstetrics and Gynecology Gestational age medicine.disease Amniotic Fluid digestive system diseases Pregnancy Trimester First Amniocentesis Coelom Gestation Female alpha-Fetoproteins business |
| Zdroj: | British journal of obstetrics and gynaecology. 98(9) |
| ISSN: | 0306-5456 |
| Popis: | Objective— The aim was to establish a normal range of alphafetoprotein (AFP) concentrations in amniotic fluid from 8 to 12 weeks gestation, and to determine any difference between AFP levels in amniotic fluid and extraembryonic coelomic fluid. Design and subjects— 150 women had a transvaginal ultrasound guided amniocentesis before termination of an apparently normal first trimester pregnancy. Separately identified samples of amniotic fluid and extraembryonic coelomic fluid were obtained and assayed by radioimmunoassay for AFP. Results— In amniotic fluid, very high levels of AFP were present at 8 weeks, levels falling rapidly up to 10 weeks after which there was a slight rise. Thus over the period 8 to 10 weeks, there was a significant inverse correlation between amniotic fluid AFP and gestational age (r= 0.67; P |
| Databáze: | OpenAIRE |
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