Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis Patients with Very Mild Clinical Disability

Autor: Anna Ghazaryan, Patrizio Pasqualetti, M. M. Filippi, Simone Migliore, Maria Giuseppina Palmieri, Doriana Landi, Ilaria Simonelli, Fabrizio Vernieri, Filomena Moffa, Ferdinando Squitieri, Giuseppe Curcio
Rok vydání: 2017
Předmět:
Adult
Male
medicine.medical_specialty
Multiple Sclerosis
Article Subject
Cognition
Cognitive Dysfunction
Executive Function
Female
Humans
Memory
Short-Term
Middle Aged
Multiple Sclerosis
Relapsing-Remitting
Neuropsychological Tests
Severity of Illness Index
Neurosciences. Biological psychiatry. Neuropsychiatry
Relapsing-Remitting
050105 experimental psychology
03 medical and health sciences
0302 clinical medicine
Physical medicine and rehabilitation
Visual memory
Memory
medicine
0501 psychology and cognitive sciences
Neuropsychological assessment
Expanded Disability Status Scale
medicine.diagnostic_test
Working memory
Multiple sclerosis
05 social sciences
adult
cognition
cognitive dysfunction
executive function
female
humans
male
memory
short-term
middle aged
multiple sclerosis
relapsing-remitting
neuropsychological tests
severity of Illness Index
General Medicine
Executive functions
medicine.disease
Neuropsychology and Physiological Psychology
Short-Term
Neurology
Physical therapy
Neurology (clinical)
Verbal memory
Psychology
030217 neurology & neurosurgery
Research Article
RC321-571
Zdroj: Behavioural Neurology, Vol 2017 (2017)
Behavioural Neurology
ISSN: 1875-8584
0953-4180
DOI: 10.1155/2017/7404289
Popis: Cognitive dysfunction affects 40–65% of multiple sclerosis (MS) patients and can occur in the early stages of the disease. This study aimed to explore cognitive functions by means of the Italian version of the minimal assessment of cognitive function in MS (MACFIMS) in relapsing-remitting MS (RRMS) patients with very mild clinical disability to identify the primarily involved cognitive functions. Ninety-two consecutive RRMS patients with Expanded Disability Status Scale (EDSS) scores ≤ 2.5 and forty-two healthy controls (HC) were investigated. Our results show that 51.1% of MS patients have cognitive dysfunction compared to HC. An impairment of verbal and visual memory, working memory, and executive functions was found in the RRMS group. After subgrouping RRMS by EDSS, group 1 (EDSS ≤ 1.5) showed involvement of verbal memory and executive functions; moreover, group 2 (2 ≤ EDSS ≤ 2.5) patients were also impaired in information processing speed and visual memory. Our results show that utilizing a comprehensive neuropsychological assessment, approximately half of MS patients with very mild physical disability exhibit cognitive impairment with a primary involvement of prefrontal cognitive functions. Detecting impairment of executive functions at an early clinical stage of disease could be useful to promptly enroll MS patients in targeted rehabilitation.
Databáze: OpenAIRE
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