The outcome of an in vitro fertilization program in women with polycystic ovary syndrome
| Autor: | Kulikowski M, D Grochowski, Waldemar Kuczyński, Slawomir Wolczynski, Szamatowicz M |
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| Rok vydání: | 1997 |
| Předmět: |
Agonist
endocrine system medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment Stimulation Fertilization in Vitro Pituitary desensitization Chorionic Gonadotropin Endocrinology Ovulation Induction Pregnancy Internal medicine medicine Humans Gynecology In vitro fertilisation Triptorelin Pamoate biology business.industry Obstetrics and Gynecology Embryo Transfer Polycystic ovary Treatment Outcome HMG-CoA reductase biology.protein Female Gonadotropin Follicle Stimulating Hormone business Hormone Polycystic Ovary Syndrome |
| Zdroj: | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 11(4) |
| ISSN: | 0951-3590 |
| Popis: | The objective of this study was to examine the efficacy of D-triptorelin in the long protocol and follicle-stimulating hormone (FSH) in an IVF-embryo transfer program in a group of patients with polycystic ovary syndrome (PCOS) who had earlier failed to respond or did not conceive after clomiphene citrate (CC)/human menopausal gonadotropin (hMG) or 'flare up' gonadotropin-releasing hormone agonist (GnRHa)/hMG stimulation. Eighty-nine women with PCOS (based on typical ultrasound criteria) had 1-3 treatment cycles without success. The stimulation protocol was changed to D-triptorelin given in midluteal phase and when pituitary desensitization was achieved, FSH administration was started. The clinical pregnancy rate per transfer in this 'negatively selected' group of PCOS patients was 29%. This was the same as the rate for a group of women with tubal factor, as was the spontaneous miscarriage rate. Although the use of GnRH agonists in the long protocol increases the costs of treatment, the number of cancelled cycles is reduced. The pregnancy rate increased in this group of women with PCOS. |
| Databáze: | OpenAIRE |
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