Anticoagulant Responses to Thrombin Are Enhanced During Regression of Atherosclerosis in Monkeys
| Autor: | Donald D. Heistad, Francis J. Miller, Steven R. Lentz, José A. Fernández, Rochelle A. Erger, John H. Griffin, Donald J. Piegors |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Endothelium Arteriosclerosis medicine.drug_class Thrombomodulin Vasodilator Agents Remission Spontaneous Thrombin Physiology (medical) Internal medicine medicine Animals Infusions Intravenous Blood Coagulation Diet Fat-Restricted Homocysteine Lung Hemostasis medicine.diagnostic_test business.industry Vascular disease Body Weight Anticoagulant Anticoagulants medicine.disease Lipids Pathophysiology Femoral Artery Vasodilation Macaca fascicularis Cholesterol medicine.anatomical_structure Endocrinology Coagulation Diet Atherogenic Partial Thromboplastin Time Cardiology and Cardiovascular Medicine business Protein C medicine.drug Partial thromboplastin time |
| Zdroj: | Circulation. 106:842-846 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.0000024982.11646.25 |
| Popis: | Background— Diet-induced atherosclerosis in monkeys produces abnormal anticoagulant responses to thrombin, including decreased generation of activated protein C (APC). We tested the hypothesis that anticoagulant responses to thrombin increase toward normal during regression of atherosclerosis. Methods and Results— Six cynomolgus monkeys were fed a high-fat atherogenic diet for 44 months and then a low-fat regression diet for 8 months. Serum total cholesterol decreased from 417±44 to 68±6 mg/dL (mean±SEM) and LDL cholesterol decreased from 375±44 to 27±5 mg/dL after the regression diet. In response to infusion of thrombin, the activated partial thromboplastin time (APTT) increased by 11±3 seconds before the regression diet and by 41±22 seconds after the regression diet ( P =0.01). The peak level of circulating plasma APC was 52±9 ng/mL before the regression diet and 88±17 ng/mL after the regression diet ( P =0.01). The APC sensitivity of plasma factor V was identical before and after the regression diet. Three additional atherosclerotic monkeys that remained on the high-fat diet for 8 months demonstrated no change in APTT or activation of protein C in response to thrombin. Conclusions— Short-term dietary regression of atherosclerosis produces enhanced anticoagulant responses to thrombin in vivo. |
| Databáze: | OpenAIRE |
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