Postpartum bleeding in women with inherited bleeding disorders: a matched cohort study
| Autor: | Bazgha Sahar, P. Batty, Shoreh Beski, Louise Bowles, Sofia Sardo Infirri, Sonia Wolf |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Haemophilia A 030204 cardiovascular system & hematology Cohort Studies Young Adult 03 medical and health sciences Blood Coagulation Disorders Inherited 0302 clinical medicine medicine Von Willebrand disease Humans Haemophilia B Young adult postpartum bleeding Obstetrics business.industry Postpartum Hemorrhage Hematology General Medicine Odds ratio medicine.disease Confidence interval Female business 030215 immunology Cohort study |
| Zdroj: | Blood Coagulation & Fibrinolysis. 31:452-458 |
| ISSN: | 1473-5733 0957-5235 |
| DOI: | 10.1097/mbc.0000000000000945 |
| Popis: | Women with inherited bleeding disorders (IBDs) are reported to have higher rates of primary and secondary postpartum haemorrhage (PPH), even with optimal haemostatic management. We evaluated whether women with IBD have higher odds of PPH compared with those without, when controlled for mode of delivery with a control group of women without IBDs. The obstetric experiences and outcomes of all women with IBD delivering at a tertiary centre between 2008 and 2017, were compared with matched controls (1 : 1). Obstetric care was provided according to national guidelines to both women with IBD and controls. Primary PPH was defined as estimated blood loss at least 500 ml. There were 46 completed pregnancies in women with IBD: 16 haemophilia A carriers, eight haemophilia B carriers, eight factor XI deficiency patients and 14 von Willebrand disease patients (type 1 = 6; type 2 = 8). No peripartum haemostatic treatment was received by carriers of haemophilia A or B. There were 74 control pregnancies. Women with IBD had higher odds of primary PPH, in a model controlling for mode of anaesthesia (adjusted odds ratio 5.30, 95% confidence interval 1.02-27.59, P = 0.048). Carriers of haemophilia A had a higher, statistically nonsignificant, odds for primary PPH than controls (adjusted odds ratio 6.85, confidence interval 0.77-60.73, P = 0.084). An increase in primary PPH was observed in women with IBD, particularly in haemophilia A, despite management according to guidelines. These results warrant further investigation and consideration should be given as to which factor levels to target. |
| Databáze: | OpenAIRE |
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