Evaluation of serum human epididymis protein 4 in patients with relapsing-remitting multiple sclerosis
| Autor: | Monika Adamczyk-Sowa, Robert Partyka, Krzysztof Wierzbicki, Danuta Kokocińska, Paweł Sowa, Bożena Adamczyk |
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| Rok vydání: | 2020 |
| Předmět: |
Male
030213 general clinical medicine medicine.medical_specialty Medicine (miscellaneous) Gastroenterology General Biochemistry Genetics and Molecular Biology Disability Evaluation 03 medical and health sciences Multiple Sclerosis Relapsing-Remitting 0302 clinical medicine Internal medicine Biomarkers Tumor Internal Medicine medicine Humans Pharmacology (medical) Prospective Studies Mesothelioma Prospective cohort study Genetics (clinical) Expanded Disability Status Scale medicine.diagnostic_test business.industry Multiple sclerosis Magnetic resonance imaging medicine.disease Epididymis Magnetic Resonance Imaging medicine.anatomical_structure Reviews and References (medical) Biomarker (medicine) Neoplasm Recurrence Local business Ovarian cancer |
| Zdroj: | Advances in Clinical and Experimental Medicine. 29:943-948 |
| ISSN: | 1899-5276 |
| Popis: | Background So far, little is known about the properties of human epididymis protein 4 (HE4) in multiple sclerosis (MS). This type 4 glycoprotein belongs to a family of genes encoding proteins whose expression is associated with the process of spermatogenesis in the epididymis. The biological function of HE4 is not fully understood. Overexpression of HE4 has been found in several malignant tumors, particularly in ovarian cancer, as well as in mesothelioma, lung, endometrial, breast, and kidney cancers. Objectives To evaluate serum HE4 in patients with relapsing-remitting multiple sclerosis (RRMS) as compared to healthy controls. Material and methods Fifty patients with RRMS undergoing first-line immunomodulatory treatment were enrolled in the prospective study. We analyzed correlations between serum HE4 levels and gender, age, disease duration, the Expanded Disability Status Scale (EDSS), annualized relapse rate (ARR), and magnetic resonance imaging (MRI) lesions. Results The patients from the study group had higher concentrations of HE4 than the subjects from the control group. Patients with EDSS > 2 had significantly higher concentrations of HE4. Positive correlations were found between HE4 concentrations and age as well as between HE4 concentrations and disease duration. No significant correlations were found between HE4 concentrations and EDSS or between HE4 concentrations and ARR. Conclusions The results of the study indicate a novel aspect of the HE4 protein in the pathomechanisms of MS. |
| Databáze: | OpenAIRE |
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