Highly enantioselective Mannich reactions with α-aryl silyl ketene acetals and imines
| Autor: | Gregory T. Notte, James L. Leighton, Jenny M. Baxter Vu |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
chemistry.chemical_classification
Silylation Aryl Organic Chemistry Enantioselective synthesis Ketene Stereoisomerism Esters Ethylenes Ketones Biochemistry Article Amino acid chemistry.chemical_compound Acetals chemistry Nitriles Organic chemistry Organosilicon Compounds Lewis acids and bases Imines Physical and Theoretical Chemistry Amino Acids |
| Zdroj: | Organic letters. 13(4) |
| ISSN: | 1523-7052 |
| Popis: | Mannich reactions with chiral silicon Lewis acid activated acylhydrazones and α-aryl silyl ketene acetals and α-aryl,α-alkyl silyl ketene imines proceed efficiently and with good to excellent levels of both diastereoselectivity and enantioselectivity. The reactions provide access to α-aryl,β-hydrazido esters and α-aryl,α-alkyl,β-hydrazido nitriles, which are valuable analogs of β-amino acids. |
| Databáze: | OpenAIRE |
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