Urinary glycosaminoglycans as risk factors for uric acid nephrolithiasis: case control study in a Sardinian genetic isolate
| Autor: | Giambattista Maestrale, Francesco Cardia, Mario Pirastu, Stefania Casula, Ginevra Biino, Paola Maria Melis, Maria Neve Ombra |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Urology Urinary system Urine Excretion chemistry.chemical_compound Kidney Calculi Recurrence Risk Factors Internal medicine medicine Humans Genetic Predisposition to Disease Glycosaminoglycans Creatinine Kidney business.industry Middle Aged medicine.disease Uric Acid Endocrinology medicine.anatomical_structure chemistry Italy Case-Control Studies Uric acid Kidney stones Female Urinary Calculi business Kidney disease |
| Zdroj: | Urology (Ridgewood N.J.) 62 (2003): 416–420. doi:10.1016/S0090-4295(03)00473-4 info:cnr-pdr/source/autori:Ombra MN, Casula S, Biino G, Maestrale G, Cardia F, Melis P, Pirastu M./titolo:Urinary glycosaminoglycans as risk factors for uric acid nephrolithiasis: case control study in a Sardinian genetic isolate./doi:10.1016%2FS0090-4295(03)00473-4/rivista:Urology (Ridgewood N.J.)/anno:2003/pagina_da:416/pagina_a:420/intervallo_pagine:416–420/volume:62 |
| ISSN: | 1527-9995 |
| DOI: | 10.1016/S0090-4295(03)00473-4 |
| Popis: | Objectives To assess the clinical association between glycosaminoglycan (GAG) excretion and uric acid (UA) nephrolithiasis by measuring urinary GAG levels in a case-control study conducted in a Sardinian genetic isolate. Inhibitors of crystallization such as GAGs seem to be involved in kidney stone formation. Methods Overnight (12-hour) urinary excretion of GAGs, calcium, oxalate, and UA were measured in urine samples from 60 patients who had formed at least one urinary stone (UA or mixed) and 52 healthy controls. The total GAG concentration was measured by a dye-binding assay, and the values were normalized against creatinine to obtain values in micrograms of GAG per milligram creatinine. Statistical analysis was performed using t tests and logistic regression analysis. Results No significant difference was found between the two groups with respect to calcium and oxalate concentrations. Nonetheless, stone formers had significantly lower levels of GAGs (29.5 ± 2.2 versus 36.4 ± 3.9 μg/mg creatinine, P = 0.003) and greater levels of UA (385.11 ± 38.2 versus 298.43 ± 31.4 mg/12 hr, P = 0.0010) than did the normal controls. Conclusions We report that the lower excretion of GAGs in stone formers could impair their inhibitory activity on UA stone formation, and, as a consequence, it may represent a risk factor for this form of urolithiasis. |
| Databáze: | OpenAIRE |
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