Muscle chemoreflex causes renal vascular constriction

Autor:	K. P. O'Hagan, Leonard B. Bell, J. Sulentic, Philip S. Clifford, Scott W. Mittelstadt
Rok vydání:	1996
Předmět:	Physiology business.industry Arteries Anatomy Vascular conductance Kidney Denervation Chemoreceptor Cells Dogs Regional Blood Flow Vasoconstriction Physiology (medical) Reflex Vascular constriction Animals Medicine Cardiology and Cardiovascular Medicine business
Zdroj:	American Journal of Physiology-Heart and Circulatory Physiology. 270:H951-H956
ISSN:	1522-1539 0363-6135
DOI:	10.1152/ajpheart.1996.270.3.h951
Popis:	The purpose of this study was to investigate the effects of the muscle chemoreflex on vascular conductance in innervated and denervated kidneys. During each experiment, six dogs ran at 10 km/h for 8-16 min, and the muscle chemoreflex was stimulated by reducing hindlimb blood flow (HLBF) (0%-74%) at 4-min intervals. Small reductions in HLBF did not cause changes in arterial blood pressure or renal vascular conductance. However, further reductions of HLBF caused increases in arterial blood pressure and decreases in renal vascular conductance. Decreases in renal vascular conductance occurred in the denervated kidneys when the HLBF was reduced below 1,500 +/- 215 ml/min and occurred in the innervated kidneys when HLBF was reduced below 1,402 +/- 161 ml/min. There was not a significant difference between the reductions in HLBF required to cause a decrease in vascular conductance in the innervated and denervated kidneys. These results demonstrate that reductions in HLBF cause decreases in renal vascular conductance, which are not dependent on renal sympathetic nerve activity.
Databáze:	OpenAIRE
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