Comparison of the effects of 7.2% hypertonic saline and 20% mannitol on whole blood coagulation and platelet function in dogs with suspected intracranial hypertension - a pilot study
Autor: | Daniel Dirkmann, Diana Henke, Judith Howard, Ivayla D. Yozova, Katja N. Adamik |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Male
Medizin Pilot Projects Hematocrit Intracranial hypertension 0403 veterinary science Cohort Studies 0302 clinical medicine Hypertonic saline Medicine Mannitol Dog Diseases Prospective Studies 610 Medicine & health Whole blood lcsh:Veterinary medicine medicine.diagnostic_test 630 Agriculture 04 agricultural and veterinary sciences General Medicine Thromboelastometry Clotting time Anesthesia Platelet function Female medicine.drug Research Article Blood Platelets Platelet Function Tests 040301 veterinary sciences Osmotherapy 03 medical and health sciences Dogs Animals Blood Coagulation Saline Solution Hypertonic Hemostasis General Veterinary business.industry Platelet Count Osmolar Concentration 030208 emergency & critical care medicine lcsh:SF600-1100 business |
Zdroj: | BMC Veterinary Research BMC Veterinary Research, Vol 13, Iss 1, Pp 1-9 (2017) Yozova, Ivayla; Howard, Judith; Henke, Diana; Dirkmann, Daniel; Adamik, Katja (2017). Comparison of the effects of 7.2% hypertonic saline and 20% mannitol on whole blood coagulation and platelet function in dogs with suspected intracranial hypertension-a pilot study. BMC veterinary research, 13(1), p. 185. BioMed Central 10.1186/s12917-017-1108-2 |
DOI: | 10.7892/boris.107547 |
Popis: | Background Hyperosmolar therapy with either mannitol or hypertonic saline (HTS) is commonly used in the treatment of intracranial hypertension (ICH). In vitro data indicate that both mannitol and HTS affect coagulation and platelet function in dogs. The aim of this study was to compare the effects of 20% mannitol and 7.2% HTS on whole blood coagulation using rotational thromboelastometry (ROTEM®) and platelet function using a platelet function analyzer (PFA®) in dogs with suspected ICH. Thirty client-owned dogs with suspected ICH needing osmotherapy were randomized to receive either 20% mannitol (5 ml/kg IV over 15 min) or 7.2% HTS (4 ml/kg IV over 5 min). ROTEM® (EXTEM® and FIBTEM® assays) and PFA® analyses (collagen/ADP cartridges) were performed before (T0), as well as 5 (T5), 60 (T60) and 120 (T120) minutes after administration of HTS or mannitol. Data at T5, T60 and T120 were analyzed as a percentage of values at T0 for comparison between groups, and as absolute values for comparison between time points, respectively. Results No significant difference was found between the groups for the percentage change of any parameter at any time point except for FIBTEM® clotting time. Within each group, no significant difference was found between time points for any parameter except for FIBTEM® clotting time in the HTS group, and EXTEM® and FIBTEM® maximum clot firmness in the mannitol group. Median ROTEM® values lay within institutional reference intervals in both groups at all time points, whereas median PFA® values were above the reference intervals at T5 (both groups) and T60 (HTS group). Conclusions Using currently recommended doses, mannitol and HTS do not differ in their effects on whole blood coagulation and platelet function in dogs with suspected ICH. Moreover, no relevant impairment of whole blood coagulation was found following treatment with either solution, whereas a short-lived impairment of platelet function was found after both solutions. |
Databáze: | OpenAIRE |
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