Pericyte mechanics and mechanobiology

Autor: Claire A Dessalles, Avin Babataheri, Abdul I. Barakat
Přispěvatelé: Département de Mécanique de l'École polytechnique (X-DEP-MECA), École polytechnique (X), Laboratoire d'hydrodynamique (LadHyX), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2021
Předmět:
Zdroj: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2021, 134 (6), pp.jcs240226. ⟨10.1242/jcs.240226⟩
ISSN: 1477-9137
0021-9533
Popis: Pericytes are mural cells of the microvasculature, recognized by their thin processes and protruding cell body. Pericytes wrap around endothelial cells and play a central role in regulating various endothelial functions, including angiogenesis and inflammation. They also serve as a vascular support and regulate blood flow by contraction. Prior reviews have examined pericyte biological functions and biochemical signaling pathways. In this Review, we focus on the role of mechanics and mechanobiology in regulating pericyte function. After an overview of the morphology and structure of pericytes, we describe their interactions with both the basement membrane and endothelial cells. We then turn our attention to biophysical considerations, and describe contractile forces generated by pericytes, mechanical forces exerted on pericytes, and pericyte responses to these forces. Finally, we discuss 2D and 3D engineered in vitro models for studying pericyte mechano-responsiveness and underscore the need for more evolved models that provide improved understanding of pericyte function and dysfunction.
Databáze: OpenAIRE
Externí odkaz: