Subversion of cytokine networks by virally encoded decoy receptors
| Autor: | Daved H. Fremont, Megan L. Epperson, Chung A. Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Chemokine
medicine.medical_treatment Viral pathogenesis Immunology Immunologic Surveillance Computational biology Poxviridae Infections medicine.disease_cause Article Viral Proteins Immune system medicine Immunology and Allergy Humans Decoy receptors Herpesviridae Immune Evasion biology Poxviridae Molecular Mimicry Herpesviridae Infections Cell biology Molecular mimicry Cytokine Host-Pathogen Interactions biology.protein Receptors Virus Receptors Chemokine Signal transduction Chemokines Signal Transduction |
| Popis: | During the course of evolution, viruses have captured or created a diverse array of open reading frames, which encode for proteins that serve to evade and sabotage the host innate and adaptive immune responses that would otherwise lead to their elimination. These viral genomes are some of the best textbooks of immunology ever written. The established arsenal of immunomodulatory proteins encoded by viruses is large and growing, and includes specificities for virtually all known inflammatory pathways and targets. The focus of this review is on herpes and poxvirus-encoded cytokine and chemokine-binding proteins that serve to undermine the coordination of host immune surveillance. Structural and mechanistic studies of these decoy receptors have provided a wealth of information, not only about viral pathogenesis but also about the inner workings of cytokine signaling networks. |
| Databáze: | OpenAIRE |
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