Effect of thymoptin on hemostasis and fibrinolysis in rats with experimental nephritis
| Autor: | T. N. Serebryakova, G. V. Andreenko, A. K. Raevskaya, L. V. Podorolskaya |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Stimulation Inflammation General Biochemistry Genetics and Molecular Biology Nephrotoxicity Internal medicine Edema Fibrinolysis medicine Animals Hemostasis Nephritis Proteinuria business.industry General Medicine medicine.disease Rats Thymosin Endocrinology Rabbits medicine.symptom business |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 146:4-8 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-008-0228-x |
| Popis: | Immune nephritis in rats was induced by administration of nephrotoxic rabbit antiserum. The development of severe renal inflammation (proteinuria, edema, lipemia, increased erythrocyte sedimentation rate, and 30% mortality) was accompanied by hypercoagulation and inhibition of fibrinolysis. Repeated subcutaneous injections of thymoptin in a low dose of 0.1 microg/200 g (5 injections every other day) increased the severity of inflammation and prethrombotic state of the blood. Lengthening the period between injections (5 injections at 5-day intervals) was followed by a tendency toward attenuation of nephritis and correction of hypercoagulation. In healthy rats, thymoptin produced an opposite effect on hemostasis, which was manifested in moderate stimulation of fibrinolysis and hypocoagulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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