Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity
| Autor: | Veronica A. Alvarez, Kevin D. Hall, Alexxai V. Kravitz, Danielle M. Friend, Jeih-San Liow, Marcelo Rubinstein, Sushil G. Rane, Kavya Devarakonda, Ioannis Papazoglou, Alanna R Kaplan, Miguel Skirzewski, Juen Guo, Timothy J. O’Neal |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Physiology Dopamine Action Potentials Mice Obese Striatum Weight Gain Obese Basal Ganglia purl.org/becyt/ford/1 [https] 0302 clinical medicine Weight loss Receptor Neurons D2 medicine.symptom CIENCIAS NATURALES Y EXACTAS Protein Binding medicine.drug medicine.medical_specialty Movement Otras Ciencias Biológicas Motor Activity Diet High-Fat Medium spiny neuron Article Ciencias Biológicas 03 medical and health sciences Physical Conditioning Animal Internal medicine Dopamine receptor D2 Weight Loss medicine Animals Humans Obesity purl.org/becyt/ford/1.6 [https] Exercise Molecular Biology Receptors Dopamine D2 business.industry Physical Activity Cell Biology medicine.disease Corpus Striatum Mice Inbred C57BL 030104 developmental biology Endocrinology business Weight gain 030217 neurology & neurosurgery |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 1550-4131 |
| Popis: | Obesity is associated with physical inactivity, which exacerbates the health consequences of weight gain. However, the mechanisms that mediate this association are unknown. We hypothesized that deficits in dopamine signaling contribute to physical inactivity in obesity. To investigate this, we quantified multiple aspects of dopamine signaling in lean and obese mice. We found that D2-type receptor (D2R) binding in the striatum, but not D1-type receptor binding or dopamine levels, was reduced in obese mice. Genetically removing D2Rs from striatal medium spiny neurons was sufficient to reduce motor activity in lean mice, whereas restoring Gi signaling in these neurons increased activity in obese mice. Surprisingly, although mice with low D2Rs were less active, they were not more vulnerable to diet-induced weight gain than control mice. We conclude that deficits in striatal D2R signaling contribute to physical inactivity in obesity, but inactivity is more a consequence than a cause of obesity. Fil: Friend, Danielle M.. National Institutes of Health; Estados Unidos Fil: Devarakonda, Kavya. National Institutes of Health; Estados Unidos Fil: O'Neal, Timothy J.. National Institutes of Health; Estados Unidos Fil: Skirzewski, Miguel. National Institutes of Health; Estados Unidos Fil: Papageorgiou, Ioannis. National Institutes of Health; Estados Unidos Fil: Kaplan, Alanna R.. National Institutes of Health; Estados Unidos Fil: Liow, Jeih San. National Institutes of Health; Estados Unidos Fil: Guo, Juen. National Institutes of Health; Estados Unidos Fil: Rane, Sushil G.. National Institutes of Health; Estados Unidos Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. University of Michigan; Estados Unidos Fil: Alvarez, Verónica A.. National Institutes of Health; Estados Unidos Fil: Hall, Kevin D.. National Institutes of Health; Estados Unidos Fil: Kravitz, Alexxai V.. National Institutes of Health; Estados Unidos |
| Databáze: | OpenAIRE |
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