Intravenous Methylcobalamin Treatment for Uremic and Diabetic Neuropathy in Chronic Hemodialysis Patients
| Autor: | Keiko Miyajima, Mitsuru Suzuki, Nakanobu Azuma, Satoshi Kuwabara, Takamichi Hattori, Ryoichi Nakazawa, Toshio Fukutake |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Diabetic neuropathy Neural Conduction Action Potentials Severity of Illness Index Diabetic Neuropathies Renal Dialysis Internal Medicine medicine Humans Vitamin B12 Aged Pain Measurement Uremia medicine.diagnostic_test business.industry Peripheral Nervous System Diseases General Medicine Middle Aged medicine.disease Surgery Vitamin B 12 Treatment Outcome Peripheral neuropathy medicine.anatomical_structure Anesthesia Chronic Disease Injections Intravenous Methylcobalamin Neuropathic pain Nerve conduction study Female business Polyneuropathy Follow-Up Studies medicine.drug Sensory nerve |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.38.472 |
| Popis: | Object: To study the effects of the intravenous administration of methylcobalamin, an analogue of vitamin B12, for uremic or uremic-diabetic polyneuropathy in patients who are receiving maintenance hemodiaiysis. An ultra-high dose of vitamin B12 has been reported to promote peripheral nerve regeneration in experimental neuropathy. Methods: Nine patients received a 500μg methylcobalamin injection 3 times a week for 6 months. The effects were evaluated using neuropathic pain grading and a nerve conduction study. Results: Serum concentrations of vitamin B12 were ultra-high during treatment due to the lack of urinary excretion. After 6 months of treatment, the patients' pain or paresthesia had lessened, and the ulnar motor and median sensory nerve conduction velocities showed significant improvement. There were no side effects. Conclusion: Intravenous methycobalamin treatment is a safe and potentially beneficial therapy for neuropathy in chronic hemodiaiysis patients.(Internal Medicine 38: 472-475, 1999) |
| Databáze: | OpenAIRE |
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