Aromatic-turmerone ameliorates DSS-induced ulcerative colitis via modulating gut microbiota in mice

Autor: Chunlian Li, Weicheng Zhang, Xianyi Wu, Qiuyang Cai, Zekai Tan, Zhengyi Hong, Shiyuan Huang, Yanghe Yuan, Lewen Yao, Lanyue Zhang
Rok vydání: 2022
Předmět:
Zdroj: Inflammopharmacology. 30:1283-1294
ISSN: 1568-5608
0925-4692
DOI: 10.1007/s10787-022-01007-w
Popis: Curcuma longa L. is one of the traditional Chinese herbs in the list of medicinal and food homology. Aromatic-turmerone is the main ingredient in turmeric essential oil. The aim of the present study is to investigate the treatment of Aromatic-turmerone on DSS-included colitis and its regulatory effect on intestinal flora disorder. Male KM mice supplemented with different concentration of aromatic-turmerone and mesalazine are subjected to 2% DSS in drinking water to induce colitis. Colon and cecum contents were collected for colitis lesion evaluation and inflammation-related gene analysis and colon contents for gut microbiota. The results show that treatments with Aromatic-turmerone significantly prevents colon shortening, alleviates the damage of colonic tissue, and reduces colonic inflammatory cytokines TNF-α and COX-2. Furthermore, the 16S rDNA gene sequence data indicate that Aromatic-turmerone improve the abundance of bacterial species, maintain some beneficial bacteria, and reduce harmful bacteria. Aromatic-turmerone downregulates the colonic inflammatory cytokines and modulates the abundance of intestinal flora, which is conductive to ameliorates DSS-induced colitis. Regularly intake of the edible herb may be help to prevent ulcerative colitis-related diseases.
Databáze: OpenAIRE
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