Sexual dysfunction in drug- naïve first episode nonaffective psychosis patients. Relationship with prolactin and psychotic symptoms. Gender differences
| Autor: | Regina Vila-Badia, M. Dolz, M J Rodriguez-Montes, E. Rubio-Abadal, N. Del Cacho, Daniel Cuadras, Anna Butjosa, Judith Usall, Daniel Muñoz-Samons |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychosis Adolescent 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Surveys and Questionnaires medicine Humans Biological Psychiatry First episode Sex Characteristics Positive and Negative Syndrome Scale business.industry Testosterone (patch) Middle Aged medicine.disease Prolactin 030227 psychiatry Psychiatry and Mental health Drug-naïve Sexual Dysfunction Physiological Sexual dysfunction Cross-Sectional Studies Psychotic Disorders Female medicine.symptom business Sexual function 030217 neurology & neurosurgery Biomarkers medicine.drug |
| Zdroj: | Psychiatry research. 289 |
| ISSN: | 1872-7123 |
| Popis: | Background Our aim is to examine differences in sexual functioning (SF) between patients with drug-naive first episode psychosis (FEP) and healthy controls (HC). We will also examine correlations between prolactin levels, testosterone levels and psychotic symptomatology with SF from a gender perspective. Methods Cross-sectional study. We included 68 FEP patients and 50 HC. A blood sample was extracted. We used the Positive and Negative Syndrome Scale to assess symptom severity, using the five factor structure according to Emsley. The Changes in Sexual Function Questionnaire (CSFQ) was administered. Results We found significantly better SF in HC than in patients (in CSFQ total score (p = 0.032) and in CSFQ Desire (p = 0.032)). A significant correlation between prolactin or testosterone and SF was not observed. We found a negative significant correlation between the disorganised subscale of the EMSLEY and total CSFQ (p = 0.027; r = −0.329), CSFQ Desire (p = 0.028; r = −0.329) and CSFQ Arousal (p = 0.026; r = −0.332) in the patient sample. In a regression model, we found sex (p = 0.003) and disorganized symptoms (p = 0.034) as significant predictors. Conclusions We found evidence for better SF in HC than in FEP patients. We could not confirm an association between prolactin or testosterone and SF. Disorganized symptomatology could be a relevant factor in SF. |
| Databáze: | OpenAIRE |
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