Down syndrome: Cytogenetical epidemiology
| Autor: | Margareta Mikkelsen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Chromosome Aberrations education.field_of_study medicine.medical_specialty Down syndrome Adolescent Denmark Incidence (epidemiology) Maternal Ages Population General Medicine Middle Aged Biology medicine.disease Epidemiology Genetics medicine Humans Female Age distribution Down Syndrome education Maternal Age Demography |
| Zdroj: | Hereditas. 86:45-49 |
| ISSN: | 0018-0661 |
| DOI: | 10.1111/j.1601-5223.1977.tb01211.x |
| Popis: | The incidence of Down syndrome throughout a period of 12 years (1960 to 1971) was unchanged about 1.15 per 1000 births in parts of greater Copenhagen. 235 liveborn infants with Down syndrome were ascertained in this period in a population of 1.2 million with a total of 204,771 births. The maternal age distribution changed considerably to younger maternal ages during the same period. The unchanged incidence may he explained partly by better ascertainment, hut exogenous factors may also play a role. Thus, a more successful treatment of threatening abortions and sick infants with Down syndrome may tend to increase the incidence. Also hormonal factors and factors influencing paternal non-disjunction which plays a significant role and satellite association patterns may he considered. |
| Databáze: | OpenAIRE |
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