Noradrenergic depletion causes sex specific alterations in the endocannabinoid system in the Murine prefrontal cortex
| Autor: | Ken Mackie, Beverly A.S. Reyes, Steven A. Thomas, M. Nitikman, E.J. Van Bockstaele, Jennifer A. Ross, M.A. Urquhart |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Diacylglycerol lipase Physiology medicine.medical_treatment Biochemistry lcsh:RC346-429 lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience Norepinephrine 0302 clinical medicine Endocrinology Fatty acid amide hydrolase Dopamine Internal medicine medicine Original Research Article Prefrontal cortex Molecular Biology lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry lcsh:Neurology. Diseases of the nervous system biology Endocrine and Autonomic Systems Chemistry lcsh:QP351-495 Endocannabinoid system 030227 psychiatry Monoacylglycerol lipase lcsh:Neurophysiology and neuropsychology biology.protein Cannabinoid 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neurobiology of Stress, Vol 10, Iss, Pp-(2019) |
| ISSN: | 2352-2895 |
| Popis: | Brain endocannabinoids (eCB), acting primarily via the cannabinoid type 1 receptor (CB1r), are involved in the regulation of many physiological processes, including behavioral responses to stress. A significant neural target of eCB action is the stress-responsive norepinephrine (NE) system, whose dysregulation is implicated in myriad psychiatric and neurodegenerative disorders. Using Western blot analysis, the protein expression levels of a key enzyme in the biosynthesis of the eCB 2-arachidonoylglycerol (2-AG), diacylglycerol lipase-α (DGL-α), and two eCB degrading enzymes monoacylglycerol lipase (MGL) and fatty acid amide hydrolase (FAAH) were examined in a mouse model that lacks the NE-synthesizing enzyme, dopamine β-hydroxylase (DβH-knockout, KO) and in rats treated with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP-4). In the prefrontal cortex (PFC), DGL-α protein expression was significantly increased in male and female DβH-KO mice (P |
| Databáze: | OpenAIRE |
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