Healing of two-wall intra-bony defects treated with a novel EMD-liquid-A pre-clinical study in monkeys
| Autor: | Richard J. Miron, Naoto Horai, Yukiya Shinohara, Kazuyuki Noguchi, Anton Sculean, Yoshinori Shirakata, Dieter D. Bosshardt, Kotaro Sena, Toshiaki Nakamura |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Reconstructive surgery Bone Regeneration Periodontal Ligament Alveolar Bone Loss Dentistry Root Planing Clinical study 03 medical and health sciences 0302 clinical medicine Dental Enamel Proteins Enamel matrix derivative medicine Animals Periodontal fiber Cementum Dental Cementum Wound Healing business.industry Regeneration (biology) Open flap debridement Haplorhini 030206 dentistry Surgery Macaca fascicularis 030104 developmental biology medicine.anatomical_structure Debridement Models Animal Guided Tissue Regeneration Periodontal Periodontics Collagen Wound healing business |
| Zdroj: | Journal of Clinical Periodontology. 44:1264-1273 |
| ISSN: | 0303-6979 |
| DOI: | 10.1111/jcpe.12825 |
| Popis: | Aim To investigate the effect of a novel enamel matrix derivative formulation (EMD-liquid or Osteogain) combined with an absorbable collagen sponge (ACS) on periodontal wound healing in intrabony defects in monkeys. Materials and Methods Chronic 2-wall intrabony defects were created at the distal aspect of 8 teeth in 3 monkeys (Macaca fascicularis). The 24 defects were randomly assigned to one of the following treatments: (1) Open flap debridement (OFD) + ACS alone, (2) OFD + Emdogain + ACS (Emdogain/ACS), (3) OFD + Osteogain + ACS (Osteogain/ACS), or (4) OFD alone. At 4 months the animals were euthanized for histologic evaluation. Results Osteogain/ACS resulted in more consistent formation of cementum, periodontal ligament and bone with limited epithelial proliferation compared to OFD alone, Emdogain/ACS, and OFD + ACS. Among the 4 treatment groups, the Osteogain/ACS group demonstrated the highest amount of regenerated tissues. However, complete periodontal regeneration was not observed in any of the defects in the 4 groups. Conclusions The present findings indicate that in 2-wall intrabony defects, reconstructive surgery with Osteogain/ACS appears to be a promising novel approach for facilitating periodontal wound healing/regeneration, thus warranting further clinical testing. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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