White Kidney Bean (Phaseolus Vulgaris L.) Consumption Reduces Fat Accumulation in a Polygenic Mouse Model of Obesity
| Autor: | Vanessa K. Fitzgerald, John N. McGinley, Linxing Yao, Tiffany L. Weir, Corey A. Lauck, Madyson R. Streeter-McDonald, Corey D. Broeckling, Henry J. Thompson, Elizabeth S. Neil, Jeremy A. Tabke, Michelle T. Foster |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male obesity Proliferation index Adipose tissue Mice Obese Mice 0302 clinical medicine Cecum Phaseolus adiposity Nutrition and Dietetics Firmicutes to Bacteroidetes ratio biology Bile acid food and beverages medicine.anatomical_structure Adipose Tissue Female lcsh:Nutrition. Foods and food supply Akkermansia muciniphila Phaseolus vulgaris medicine.medical_specialty medicine.drug_class lcsh:TX341-641 030209 endocrinology & metabolism Ileum Feed conversion ratio Article Bile Acids and Salts 03 medical and health sciences Internal medicine medicine Animals bile acids white kidney bean biology.organism_classification gut health Diet Mice Inbred C57BL Disease Models Animal 030104 developmental biology Endocrinology Farnesoid X receptor farnesoid X receptor Food Science |
| Zdroj: | Nutrients Volume 11 Issue 11 Nutrients, Vol 11, Iss 11, p 2780 (2019) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu11112780 |
| Popis: | Clinical studies indicate that eating common bean, Phaseolus vulgaris L., plays a role in body weight regulation but mechanisms have yet to be elucidated. Here, we investigated the anti-obesogenic activity of white kidney bean in a mouse model of dietary-induced obesity. Bean consumption reduced the accumulation of adipose tissue in male and female C57BL6 mice. The anti-obesogenic effect of white kidney bean was not due to alterations in energy intake, energy excreted in the feces, or feed efficiency ratio. While bean consumption increased the mass of the intestine, no marked differences were consistently observed in crypt height, mucin content of goblet cells, proliferation index or zone of proliferation. However, significantly higher concentrations of total bacteria and of Akkermansia muciniphila were detected in cecal content of bean-fed mice, and the ratio of Firmicutes to Bacteroidetes was reduced. Bile acid content was higher in the ileum of bean-fed mice, but transcript levels of farnesoid X receptor were not significantly affected. Whether changes in bile-acid-mediated cell signaling play a role in bean-related differences in fat accumulation and/or overall metabolic health requires further investigation. |
| Databáze: | OpenAIRE |
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