High Levels of Chronic Immune Activation in the T-Cell Compartments of Patients Coinfected with Hepatitis C Virus and Human Immunodeficiency Virus Type 1 and on Highly Active Antiretroviral Therapy Are Reverted by Alpha Interferon and Ribavirin Treatment
Autor: | Veronica D. Gonzalez, Alex Lund Laursen, Karolin Falconer, Nina Weis, Johan K. Sandberg, Annette Alaeus, Kim Blom, Birgitte Mørn, Olle Reichard |
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Rok vydání: | 2009 |
Předmět: |
Adult
Male T-Lymphocytes T cell Hepatitis C virus Immunology Alpha interferon HIV Infections Hepacivirus Biology Lymphocyte Activation medicine.disease_cause Antiviral Agents Microbiology Virus Young Adult T-Lymphocyte Subsets Interferon Antiretroviral Therapy Highly Active Virology Ribavirin medicine Humans Interferon alfa Interferon-alpha virus diseases Hepatitis C Chronic Middle Aged Viral Load medicine.disease ADP-ribosyl Cyclase 1 digestive system diseases medicine.anatomical_structure Insect Science Disease Progression HIV-1 Coinfection Pathogenesis and Immunity Female Viral load medicine.drug |
Zdroj: | BASE-Bielefeld Academic Search Engine |
ISSN: | 1098-5514 0022-538X |
Popis: | Chronic immune activation is a driver of human immunodeficiency virus type 1 (HIV-1) disease progression. Here, we describe that subjects with chronic hepatitis C virus (HCV)/HIV-1 coinfection display sharply elevated immune activation as determined by CD38 expression in T cells. This occurs, despite effective antiretroviral therapy, in both CD8 and CD4 T cells and is more pronounced than in the appropriate monoinfected control groups. Interestingly, the suppression of HCV by pegylated alpha interferon and ribavirin treatment reduces activation. High HCV loads and elevated levels of chronic immune activation may contribute to the high rates of viral disease progression observed in HCV/HIV-1-coinfected patients. |
Databáze: | OpenAIRE |
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