Prognostic significance of miR‐21 and PDCD4 in patients with stage II esophageal carcinoma after surgical resection
| Autor: | Chuanshan Yao, Quanxiao Xu, Daimeng Shi, Jiandong Zhang, Limin He, Penghao Wen, Zhen Zhang, Xulin Zhao, Lei Ma |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Surgical resection Oncology medicine.medical_specialty Esophageal Neoplasms medicine.medical_treatment Stage ii Biochemistry Disease-Free Survival law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Carcinoma Humans In patient RNA Neoplasm Molecular Biology Aged Neoplasm Staging Chemotherapy business.industry RNA-Binding Proteins Cell Biology Middle Aged medicine.disease Neoplasm Proteins Gene Expression Regulation Neoplastic Survival Rate MicroRNAs 030104 developmental biology Tumor progression 030220 oncology & carcinogenesis T-stage Female Apoptosis Regulatory Proteins business |
| Zdroj: | Journal of Cellular Biochemistry. 119:4783-4791 |
| ISSN: | 1097-4644 0730-2312 |
| DOI: | 10.1002/jcb.26672 |
| Popis: | Many studies have shown that randomized clinical trial with long-term follow-up found no improvement in stage II esophageal carcinoma (EC) patients receiving preoperative neoadjuvant chemoradiotherapy or chemotherapy treatment, this limitation underscored the urgent need for novel and reliable biomarkers for prognosis and prediction in stage II EC. miR-21 is frequently over-expressed while programmed cell death 4 (PDCD4) is often down-regulated in solid tumors. This study aimed to investigate the clinicopathological and prognostic significance of miR-21 and PDCD4 expression and to elucidate any correlation between miR-21 and PDCD4 expression in stage II EC patients. The expression level of miR-21 was up-regulated while the PDCD4 protein was down-regulated in stage II EC tissues compared with the adjacent non-cancerous tissues. Analyses of the clinicopathological parameters indicated that miR-21 expression was associated with differentiation grade, T stage, and N stage. PDCD4 protein expression was associated with T stage, N stage, and tumor size. The univariate linear regression analysis suggested a significant negative correlation between miR-21 and PDCD4 expression. The Kaplan-Meier curve showed that high miR-21 expression or low PDCD4 expression predicted poor progression-free survival (PFS) and overall survival (OS) of patients with stag II EC. In conclusion, both up-regulated miR-21 and down-regulated PDCD4 expression were associated with the aggressive progression and poor prognosis of stage II EC. miR-21 and PDCD4 might be potential biomarkers of tumor progression and indicators of prognosis of stag II EC. |
| Databáze: | OpenAIRE |
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