Dim light at night exacerbates stroke outcome
| Autor: | Jacob R. Bumgarner, Zachary M. Weil, Randy J. Nelson, William H. Walker, O. Hecmarie Meléndez-Fernández, Ning Zhang, A. Courtney DeVries, Jennifer A. Liu, Laura K. Fonken |
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| Rok vydání: | 2020 |
| Předmět: |
Photoperiod
medicine.medical_treatment Physiology Endogeny Anxiety Article Light at night Lesion Mice 03 medical and health sciences 0302 clinical medicine Rhythm medicine Animals Humans Circadian rhythm Stroke Neuroinflammation 030304 developmental biology Neurons 0303 health sciences business.industry General Neuroscience medicine.disease Circadian Rhythm Disease Models Animal medicine.symptom Stroke recovery business 030217 neurology & neurosurgery |
| Zdroj: | Eur J Neurosci |
| ISSN: | 1460-9568 0953-816X |
| DOI: | 10.1111/ejn.14915 |
| Popis: | Circadian rhythms are endogenous biological cycles that synchronize physiology and behaviour to promote optimal function. These ~24-hr internal rhythms are set to precisely 24 hr daily by exposure to the sun. However, the prevalence of night-time lighting has the potential to dysregulate these biological functions. Hospital patients may be particularly vulnerable to the consequences of light at night because of their compromised physiological state. A mouse model of stroke (middle cerebral artery occlusion; MCAO) was used to test the hypothesis that exposure to dim light at night impairs responses to a major insult. Stroke lesion size was substantially larger among animals housed in dLAN after reperfusion than animals maintained in dark nights. Mice housed in dLAN for three days after the stroke displayed increased post-stroke anxiety-like behaviour. Overall, dLAN amplified pro-inflammatory pathways in the CNS, which may have exacerbated neuronal damage. Our results suggest that exposure to LAN is detrimental to stroke recovery. |
| Databáze: | OpenAIRE |
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