Chemical and physical chitosan hydrogels as prospective carriers for drug delivery: a review
| Autor: | Yu Tian, Jiayue Liu, Shiyao Hua, Bingren Tian |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Biocompatibility
Biomedical Engineering Nanotechnology macromolecular substances complex mixtures Preparation method Chitosan chemistry.chemical_compound Drug Delivery Systems Animals Humans General Materials Science Drug Carriers Low toxicity Chemistry technology industry and agriculture Hydrogels General Chemistry General Medicine equipment and supplies Biological materials carbohydrates (lipids) Self-healing hydrogels Drug delivery Drug release |
| Zdroj: | Journal of Materials Chemistry B. 8:10050-10064 |
| ISSN: | 2050-7518 2050-750X |
| DOI: | 10.1039/d0tb01869d |
| Popis: | With the advancement of medical research, the source and preparation of biological materials have gradually attracted attention. Hydrogels prepared from natural polysaccharides have been extensively applied in the medical field. The biocompatibility, excellent degradability and low toxicity of chitosan have favored the use of chitosan hydrogels as prospective carriers for drug delivery. Special chitosan hydrogels that effectively release target drugs based on different environmental stimuli have also been developed. This article reviews recent research progress in the development of chemical and physical chitosan hydrogels for drug delivery. In particular, preparation methods together with the chemical and physical properties of chitosan hydrogels are summarized. We also discuss multiple mechanisms of drug release from chitosan hydrogels. Finally, we highlight the future prospects of chitosan hydrogels in medical research. |
| Databáze: | OpenAIRE |
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