Changes in serotype prevalence and antimicrobial resistance among invasive Streptococcus pneumoniae isolates in Korea, 1996–2008
| Autor: | Yeon-Ho Kang, Sungkyoung Lee, Songmee Bae, Kwang-Jun Lee, Jae-Yon Yu |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Microbiology (medical) Serotype Cefotaxime Adolescent Tetracycline Erythromycin Microbial Sensitivity Tests Biology medicine.disease_cause Microbiology Pneumococcal Infections Young Adult Age Distribution Antibiotic resistance Drug Resistance Multiple Bacterial Republic of Korea Streptococcus pneumoniae Prevalence medicine Humans Serotyping Child Aged Aged 80 and over Infant Clindamycin General Medicine Middle Aged Anti-Bacterial Agents Vaccination Child Preschool Female medicine.drug |
| Zdroj: | Journal of Medical Microbiology. 62:1204-1210 |
| ISSN: | 1473-5644 0022-2615 |
| DOI: | 10.1099/jmm.0.058164-0 |
| Popis: | We investigated changes in serotypes and antimicrobial susceptibilities among 386 isolates of invasive Streptococcus pneumoniae collected from numerous hospitals in Korea from 1996 to 2008. Serotypes 19F (9.8 %), 23F (8.3 %), 19A (7.8 %), 6A (7.5 %), 3 (7.3 %), 9V (6.5 %), 6B (6.2 %), 14 (4.9 %), 1 (3.9 %), 11A (3.9 %) and 4 (3.1 %) represented 69.2 % of all isolates. While the overall proportion of PCV7 serotypes was stable over time, we observed modest decreases in children S. pneumoniae isolates showed high resistance rates to erythromycin (74.9 %), tetracycline (71.1 %) and clindamycin (61.7 %). Between 1996–2003 and 2004–2008, non-susceptibility rates to cefotaxime and multi-drugs (three or more classes) in PCV7 serotypes showed a declining trend, while in non-PCV7 serotypes there was an increasing trend. Non-PCV7 serotypes 6A and 19A, which mostly exhibited multidrug-resistant phenotypes (69.0 % and 76.7 % respectively), increased between 1996–2003 and 2004–2008. Although PCV7 was introduced in Korea in November 2003, pneumococcal vaccination has not been included in the national child vaccination programme. Our results provide details of serotype occurrence that will be useful when adoption of universal pneumococcal vaccination in Korea is being considered. |
| Databáze: | OpenAIRE |
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