Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: A role in innate immunity?
| Autor: | Petr Vanhara, Katarína Múčková, Eva Lzicarova, Zdenka Krenova, Leos Kren, Radek Lakomy, Ondrej Slaby, Václav Vybíhal, Pavel Fadrus, Tomáš Svoboda, Jaroslav Michálek, Martin Smrčka, Marek Sova |
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| Rok vydání: | 2010 |
| Předmět: |
Immunology
Cell Cell Communication Human leukocyte antigen Biology Immunomodulation 03 medical and health sciences 0302 clinical medicine Immune system HLA-E Cell Movement HLA Antigens Immunity HLA-G medicine Humans Immunology and Allergy Gliosis 030304 developmental biology HLA-G Antigens 0303 health sciences Innate immune system Microglia Brain Neoplasms Macrophages Histocompatibility Antigens Class I Brain Immunity Innate medicine.anatomical_structure Neurology 030220 oncology & carcinogenesis Cancer research Neurology (clinical) Glioblastoma |
| Zdroj: | Journal of Neuroimmunology. 220:131-135 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2010.01.014 |
| Popis: | The possible role of immune-modulatory nonclassical molecules HLA-G and HLA-E in an anti-tumoral response and development of glioblastoma is not well characterized. In this study, we evaluated an expression of HLA-G and HLA-E by activated tumor infiltrating microglia/macrophages. We found production of HLA-G and HLA-E by tumor infiltrating activated microglia/macrophages in a majority of glioblastomas. We speculate that the expression of these molecules by activated microglia/CNS macrophages plays a role in the anti-tumoral immunity in the development of glioblastoma. Mechanisms of microglia–glioblastoma cell interactions with respect to the expression of these molecules deserves further study. |
| Databáze: | OpenAIRE |
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