Participation of voltage-gated sodium and calcium channels in the acute cardiac effects of toluene

Autor:	Daniel Godínez-Hernández, M Carreón-Garcidueñas, Luis Fernando Ortega-Varela, N Alvarado-Gómez, Marcia Yvette Gauthereau-Torres, Claudia Cervantes-Durán
Rok vydání:	2018
Předmět:	Male Cardiac function curve medicine.medical_specialty Calcium Channels L-Type Epinephrine Lidocaine Heart Ventricles Health Toxicology and Mutagenesis 030204 cardiovascular system & hematology Toxicology NAV1.5 Voltage-Gated Sodium Channel 03 medical and health sciences 0302 clinical medicine Nifedipine Heart Rate Coronary Circulation Internal medicine medicine Animals Rats Wistar Inhalation Exposure Dose-Response Relationship Drug Voltage-dependent calcium channel Voltage-gated ion channel Chemistry Sodium channel Calcium channel Heart Function Tests Solvents cardiovascular system Cardiology 030217 neurology & neurosurgery Toluene medicine.drug
Zdroj:	Toxicology Mechanisms and Methods. 28:670-677
ISSN:	1537-6524 1537-6516
DOI:	10.1080/15376516.2018.1491664
Popis:	Inhaling solvents can lead to occurrence of cardiac arrhythmias and sudden sniffing death. Mechanisms related to this phenomenon are not fully understood. The purpose of this study was to investigate the effect of acute toluene exposure on heart reactivity to epinephrine and the participation of voltage-gated sodium and calcium channels. We found that acute toluene exposure increased perfusion pressure, left ventricular developed pressure, and heart rate. These actions were inhibited by lidocaine and nifedipine. Our results suggest that acute toluene exposure modify voltage-gated sodium and calcium channel function and expression likely due to a cardiac adrenergic mechanism and these effects could be participating, at least in part, in the presence of cardiac arrhythmias. To our best knowledge, this is the first report to establish a direct participation of voltage-gated Na+ and Ca2+ channels, toluene and epinephrine on cardiac function in rats.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf8b802739dfcafbb1feddc7ae77e4b https://doi.org/10.1080/15376516.2018.1491664 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.